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Home>Research and Development>Intellectual Property>Research Papers>Medical and Pharmaceutical Science
Title The author Journal
Structure of the ligand-binding domain of rat VDR in complex with the nonsecosteroidal vitamin D3 analogue YR301 Kakuda, Shinji; Okada, Kazuhisa; Eguchi, Hiroshi; Takenouchi, Kazuya; Hakamata, Wataru; Kurihara, Masaaki; Takimoto-Kamimura, Midori Acta Crystallographica, Section F: Structural Biology and Crystallization Communications (2008), F64(11), 970-973
In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition Mukoyoshi, M.; Nishimura, S.; Hoshide, S.; Umeda, S.; Kanou, M.; Taniguchi, K.; Muroga, H. Xenobiotica (2008), 38(5), 496-510
Pharmacological properties and clinical effects of the inhaled corticosteroid ciclesonide (Alvesco inhaler) for treatment of asthma Nonaka, Takashi; Katsuura, Yasuhiro; Sugiyama, Hiroyuki; Miyagi, Fuminori Nippon Yakurigaku Zasshi (2008), 132(4), 237-243
Role of the tumor necrosis factor-α, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model Iwabuchi, Sadahiro; Ito, Masaya; Chikanishi, Toshihiro; Azuma, Yoshiaki; Haro, Hirotaka Journal of Orthopaedic Research (2008), 26(9), 1274-1278
1α, 25-Dihydroxyvitamin D3-26, 23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells Ishizuka, Seiichi; Kurihara, Noriyoshi; Hiruma, Yuko; Miura, Daishiro; Namekawa, Jun-ichi; Tamura, Azusa; Kato-Nakamura, Yuko; Nakano, Yusuke; Takenouchi, Kazuya; Hashimoto, Yuichi; Nagasawa, Kazuo; Roodman, G. David Journal of Steroid Biochemistry and Molecular Biology (2008), 110(3-5), 269-277
Complex of human neutrophil elastase with 1/2SLPI Koizumi, Masahiro; Fujino, Aiko; Fukushima, Kay; Kamimura, Takashi; Takimoto-Kamimura, Midori Journal of Synchrotron Radiation (2008), 15(3), 308-311
Effect of honeycomb-patterned structure on chondrocyte behavior in vitro Fukuhira, Yukako; Kaneko, Hiroaki; Yamaga, Mika; Tanaka, Masaru; Yamamoto, Sadaaki; Shimomura, Masatsugu Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2008), 313+314, 520-525
Novel and extensive aspects of paraquat-induced pulmonary fibrogenesis: Comparative and time-course microarray analyses in fibrogenic and non-fibrogenic rats Satomi, Yoshihide; Sakaguchi, Kazuko; Kasahara, Yoshinori; Akahori, Fumiaki Journal of Toxicological Sciences (2007), 32(5), 529-553
Analysis of protein-low molecular compound interaction using surface plasmon resonance (SPR) biosensor Suwa, Yorimasa; Namiki, Naoko Jikken Igaku Bessatsu (2007), JB19(Bunshikan Sogo Sayo Kaiseki Handobukku), 230-235
Ciclesonide uptake and metabolism in human alveolar type II epithelial cells (A549) Nonaka, Takashi; Nave, Rudiger; McCracken, Nigel; Kawashimo, Atsuko; Katsuura, Yasuhiro BMC Pharmacology (2007), 7, No pp. given
Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa Sato, Hideyuki; Nave, Ruediger; Nonaka, Takashi; Yoshihisa, Nishibe; Atsuhiro, Nagano; Mochizuki, Tsutomu; Takahama, Shigehiro; Kondo, Shiro; Wingertzahn, Mark BMC Pharmacology (2007), 7, No pp. given
A novel acetyl-CoA carboxylase inhibitor reduces de novo fatty acid synthesis in HepG2 cells and rat primary hepatocytes Sugimoto, Yoshinori; Naniwa, Yoshimitsu; Nakamura, Takayuki; Kato, Hirotsugu; Yamamoto, Masanori; Tanabe, Hirofumi; Inoue, Kinji; Imaizumi, Atsushi Archives of Biochemistry and Biophysics (2007), 468(1), 44-48
Animal models of osteoporosis and development of anti-osteoporotic agents Azuma, Yoshiaki Nippon Yakurigaku Zasshi (2007), 130(3), 201-205
Development of affinity resin method using bioactive peptides as ligands Furuya, Minoru Baiotekunoroji Janaru (2007), 7(4), 468-471
Repair of osteochondral defects with a new porous synthetic polymer scaffold Sumi, Y. et al. The Journal of Bone and Joint Surgery (Br) (2007), 89-B, 258-264
Tissue engineering using nanofiber Teijin Ltd. Japan Miyoshi, Takanori Kobunshi (2006), 55(3), 155
Biodegradable honeycomb-patterned film composed of poly (lactic acid) and L-α-Dioleoyl Phosphatidylethanolamine Department of Tissue Engineering Development, Innovation Research Institute, Teijin Ltd. Fukuhira, Yukako; Kitazono, Eiichi; Hayashi, Takami; Kaneko, Hiroaki; Tanaka, Masaru; Shimomura, Masatsugu; Sumi, Yoshihiko Biomaterials (2006), 27(9), 1797-1802
Functional chemokine receptors in allergic diseases: it CCR8 a novel therapeutic target? Pharma-ceutical Discovery Research Laboratories, Institute for Biomedical Research, Teijin Pharma., Ltd. Mitsuyama, E.; Kunori, Y.; Kamimura, T.; Kaminuma, O. Mini-Reviews in Medicinal Chemistry (2006), 6(4), 463-466
Enhancement of Transformed Foci and Induction of Prostaglandins in Balb/c 3T3 Cells by Palytoxin: In Vitro Model Reproduces Carcinogenic Responses in Animal Models Regarding the Inhibitory Effect of Indomethacin and Reversal of Indomethacin's Effect by Exogenous Prostaglandins Pharmacology and Safety Research Department, Pharma-ceutical Development Research Laboratories, TEIJIN Pharma Ltd. Miura, Daishiro; Kobayashi, Mitsuru; Kakiuchi, Satoko; Kasahara, Yoshinori; Kondo, Shiro Toxico-logical Sciences (2006), 89(1), 154-163
Flow cytometric analysis of erythropoietic abnormality: Changes in the cell maturity index of reticulocytes and retic distribution index are useful as indicators of erythropoietic toxicity in non-clinical studies Pharmacology and Safety Research Department, Pharma-ceutical Development Research Laboratories, TEIJIN Pharma Ltd. Kakiuchi, Satoko; Kobayshi, Mitsuru; Satomi, Yoshihide; Miura, Daishiro; Kasahara, Yoshinori; Kondo, Shiro Journal of Toxico-logical Sciences (2006), 31(2), 111-122
Active vitamin D3 and related syndromes TEIJIN Pharma Ltd. Ishii, Shigeyuki Saibo (2006), 38(5), 203-206
Development of affinity chromatography using a bioactive peptide as a ligand Pharma-ceutical Discovery Research Laboratories, Teijin Pharma Ltd.Teijin Institute for Bio-medical Research Furuya, Minoru; Tsushima, Yu; Tani, Shinobu; Kamimura, Takashi Bioorganic & Medicinal Chemistry (2006), 14(15), 5093-5098
Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-α-induced IL-8 secretion in the human airway epithelial cell line NCI-H292 Bio-medical Evaluation Research Department, Pharma-ceutical Discovery Research Laboratories, Teijin Pharma Ltd. Chokki, Manabu; Mitsuhashi, Hiroaki; Kamimura, Takashi Life Sciences (2006), 78(26), 3051-3057
Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoyl- phosphatidylethanolamine Fukuhira, Y.; Kitazono, E.
Hayashi, T.; Kaneko, H.
Sumi, Y. et al.		 Biomaterials (2006), 27(9), 1797-1802
Development of a Novel Temporary Epicardial Pacing Wire With Biodegradable Film Fukuhira, Y.; Kitazono, E. Kaneko, H.; Sumi, Y. et al. The Annals of Thoracic Surgery (2006), 82(4), 1489-1493
In vitro evaluation of low-intensity pulsed ultrasound in herniated disc resorption Iwabuchi, Sadahiro; Ito, Masaya; Hata, Junko; Chikanishi, Toshihoro; Azuma, Yoshiaki; Haro, Hirotaka Biomaterials (2005), 26(34), 7104-7114
The antagonism between 2-methyl-1, 25-dihydroxyvitamin D3 and 2-methyl-20-epi-1, 25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1α, 25-dihydroxyvitamin D3 assessed by NB4 cell differentiation Miura, Daishiro; Norman, Anthony W.; Mizwicki, Mathew T.; Fujishima,Toshie; Konno, Katsuhiro; Kittaka, Atsushi; Takayama, Hiroaki; Ishizuka, Seiichi Journal of Steroid Biochemistry and Molecular Biology (2005), 94(5), 469-479
Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1α-hydroxyvitamin D3-26, 23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin D receptor Ochiai, Eiji; Miura, Daishiro; Eguchi, Hiroshi; Ohara, Sachiko; Takenouchi, Kazuya; Azuma, Yoshiaki; Kamimura, Takashi; Norman, Anthony W.; Ishizuka, Seiichi Molecular Endo-crinology (2005), 19(5), 1147-1157
Effect of nonspecific binding to microsomes and metabolic elimination of buprenorphine on the inhibition of cytochrome P4502D6 Umeda, Shin; Harakawa, Noriko; Yamamoto, Masanori; Ueno, Koichi Biological & Pharma-ceutical Bulletin (2005), 28(2), 212-216
Effects of alendronate on bone metabolism Ohta, Tomohiro Bone (Osaka, Japan) (2005), 19(1), 41-48
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase Takano, Yasuhiro; Hase-Aoki, Kumiko; Horiuchi, Hideki; Zhao, Lin; Kasahara, Yoshinori; Kondo, Shiro; Becker, Michael A. Life Sciences (2005), 76(16), 1835-1847
(23S)-25-dehydro-1α-hydroxyvitamin D3-26, 23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease Ishizuka, Seiichi; Kurihara, Noriyoshi; Reddy, Sakamuri V.; Cornish, Jillian; Cundy, Tim; Roodman, G. David Endo-crinology (2005), 146(4), 2023-2030
Rho GTPase activation is a key step in renal epithelial mesenchymal transdifferentiation Patel, Sharmila; Takagi, Ken-ichro; Suzuki, Jun; Imaizumi, Atsushi;Kimura, Tsuyoshi; Mason, Roger M.; Kamimura, Takashi; Zhang, Zhi Journal of the American Society of Nephrology (2005), 16(7), 1977-1984
TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) Kasai, Hidenori; Allen, Jeremy T.; Mason, Roger M.; Kamimura, Takashi; Zhang, Zhi Respiratory Research (2005), 6(1), No pp. given
Pharmacokinetics of nasal powder formulations Makino, Yuji; Nishibe, Yoshihisa; Matsugi, Hideo; Nishimura, Yoshitaka; Katsuyama, Iwao Drug Delivery System (2005), 20(6), 656-665
Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF α-converting enzyme activity in airway epithelial cells Chokki, Manabu; Eguchi, Hiroshi; Hamamura, Ichiro; Mitsuhashi, Hiroaki; Kamimura, Takashi FEBS Journal (2005), 272(24), 6387-6399
Species Differences in Angiotensin II Generation and Degradation by Mast Cell Chymases Kunori, Yuichi; Muroga, Yumiko; Iidaka, Minako; Mitsuhashi, Hiroaki; Kamimura, Takashi; Fukamizu, Akiyoshi Journal of Receptors and Signal Transduction (2005), 25(1), 35-44
Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D3 antagonists Takenouchi, Kazuya; Sogawa, Ryo; Manabe, Kenji; Saitoh, Hiroshi; Gao,Qingzhi; Miura, Daishiro; Ishizuka, Seiichi Journal of Steroid Biochemistry and Molecular Biology (2004), 89-90(1-5), 31-34
Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1a, 25-dihydroxyvitamin D3 from pagetic bone marrow cells Ishizuka, Seiichi; Kurihara, Noriyoshi; Miura, Daishiro; Takenouchi, Kazuya; Cornish, Jillian; Cundy, Tim; Reddy, Sakamuri V.; Roodman, G. David Journal of Steroid Biochemistry and Molecular Biology (2004), 89-90(1-5), 331-334
Effects of vitamin D on bone quality Azuma, Yoshiaki; Harada, Yoshifumi; Ishizuka, Seiichi; Kamimura, Takashi Clinical Calcium (2004), 14(4), 612-620
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells American Chokki, Manabu; Yamamura, Satoshi; Eguchi, Hiroshi; Masegi, Tsukio; Horiuchi, Hideki; Tanabe, Hirofumi; Kamimura, Takashi; Yasuoka, Susumu Journal of Respiratory Cell and Molecular Biology (2004),30(4), 470-478
Crystal structure of the complex of porcine pancreatic elastase with TEI-8362 Koizumi, Masahiro; Muratani, Emiko; Fujii, Katsuhiko; Takimoto-Kamimura, Midori Journal of Synchrotron Radiation (2004), 11(1), 101-104
Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation Nightingale, Joanna; Patel, Sharmila; Suzuki, Naotaka; Buxton, Roger Takagi, Ken-Ichro; Suzuki, Jun; Sumi, Yoshihiko; Imaizumi, Atsushi; Mason, Roger M.; Zhang, Zhi Journal of the American Society of Nephrology (2004), 15(1), 21-32

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